Simultaneous Determination of Levodopa and BenserazideUsing Derivative Spectrophotometry: Levodopa ve Benserazid'in Türev Spektrofotometrisi ile Birarada Tayini
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Simultaneous Determination of Losartan and Hydrochlorothiazide in Pharmaceutical Preparations by Derivative and Ratio Derivative Spectrophotometry
Background & Aims: Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin II receptors. Hyzaar® is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, ...
متن کاملSimultaneous Derivative Spectrophotometric Determination of Levodopa and Carbidopa in Pharmaceutical Preparations
The present work reports on the investigations based on the interaction of sodium hydroxide with catechol derivatives. The first derivative spectra allowed the simultaneous determination of levodopa and carbidopa. The calibration graph was constructed from the first derivative signals by measuring D at 350 nm for standard samples containing between 3 and 30 mg L−1 of levodopa and at 305 nm for ...
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متن کاملSimultaneous chemiluminometric determination of levodopa and benserazide in a multi-pumping flow system with multivariate calibration.
An automated multi-pumping flow system is proposed for the simultaneous chemiluminometric determination of benserazide and levodopa using multivariate calibration methods. The developed methodology is based on chemiluminescence (CL) emission generated by the reaction of benserazide with luminol, and on a concurrent inhibiting effect of levodopa on this reaction. A multi-pumping flow system comp...
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A simple and sensitive methodology for the simultaneous determination of levodopa and carbidopa in pharmaceutical samples is described. The method combines the advantages of fluorescence with partial least-squares (PLS) analysis, and requires no previous separation steps. The developed method is based on the oxidation of levodopa and carbidopa by cerium(IV) in a sulfuric acid medium and monitor...
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ژورنال
عنوان ژورنال: Ankara Universitesi Eczacilik Fakultesi Dergisi
سال: 1994
ISSN: 1015-3918
DOI: 10.1501/eczfak_0000000146